Search results for " canali"
showing 6 items of 6 documents
Predictors of mortality and early detection strategies for hepatopulmonary syndrome in liver transplant patients☆
2016
Introduction: Hepatopulmonary syndrome (HPS) is a serious, progressive disease. Its pathophysiology resides in a hypoxic intrapulmonary shunt and severe clinical deterioration. Liver transplantation (LT) is the only effective treatment in appropriately selected patients. Objective: To acknowledge the importance of early diagnosis of HPS. Patients and methods: Observational, descriptive, retrospective trial including 8 patients with HPS that received LT between April 2006 and August 2014. The clinical data prior to transplantation and follow-up after the procedure were reviewed. A multivariate analysis (stepwise forward logistic regression analysis) was used to identify the variable that cou…
Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes
2018
INTRODUCTION: Sandwich-cultured rat hepatocytes (SCRH) have become an invaluable in vitro model to study hepatic drug disposition. SCRH are maintained between two layers of extracellular matrix. In this configuration, culture periods of 4days are typically applicable. The aim of the present study was to modify conventional SCRH by applying an additional collagen overlay to prolong the hepatic phenotype in SCRH and thus to extend the applicability of the model. METHODS: The cultures receiving an extra top layer ('SCRH-plus' cultures) were compared with the conventional SCRH by testing the morphology, cell functionality, metabolic capacity and Mrp2-activity. RESULTS: In the SCRH-plus cultures…
The landscape of strongholds
2016
La difesa dei territori ha offerto risultati straordinari alla formazione e alla trasformazione del territorio e del paesaggio, a volte con tratti spettacolari e dimensioni incredibili. La celebrazione del centenario dell’inizio della Prima guerra mondiale ha offerto lo spunto per una riflessione sulle ricadute indotte sul paesaggio dagli eventi bellici, e più in generale dalla realizzazione di strutture difensive e del loro rapporto con il paesaggio circostante. Territorial defence led to extraordinary results in terms of forming and transforming the territory and landscape, at times with spectacular sights and incredible sizes. The one hundred year anniversary since the beginning of the F…
Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent.
2018
Abstract Cholestasis represents a major subtype of drug-induced liver injury and novel preclinical models for its prediction are needed. Here we used primary human hepatocytes (PHH) from different donors in 2D-sandwich (2D-sw) and/or 3D-spheroid cultures to study inter-individual differences in the response towards cholestatic hepatotoxins after short-term (48–72 hours) and long-term repeated exposures (14 days). The cholestatic liabilities of drugs were determined by comparing cell viability upon exposure to the highest non-cytotoxic drug concentration in the presence and absence of a non-cytotoxic concentrated bile acid mixture. In 2D-sw culture, cyclosporine A and amiodarone presented cl…
Inclusive Design for Alzheimer’s Disease: Low-cost Treatments, Design and ICT
2019
Inability to acquire new memories, difficulty to remember recent events and to recognize objects, places and people, visual-spatial disorientation, these are some of the disorders with which who is affected by neurological diseases must learn to live with. In a continuously evolving society, where the decreasing birth rate and the drops in mortality are consistent, the job of Architecture is precisely to interpret the requirements and needs of people who have lost the canonical relationship with the world and give them the possibility to recover it or maintain it through communication channels that use their remaining ability to understand. The indoors and outdoors acquire a “prosthesis fun…
Ultrastructural biologic effects of sonography with pulse inversion and microbubble contrast in rabbit liver
2005
Purpose This prospective study was conducted to evaluate the biologic effects of microbubble destruction with pulse-inversion harmonic imaging on rabbit liver parenchyma. Methods The livers of 6 albino rabbits were examined sonographically by a single investigator. Three rabbits underwent contrast-enhanced sonography, with scanning starting 5 seconds after injection by using pulse-inversion harmonic imaging with a mechanical index of 1.2. Four time-triggered images were recorded at a rate of 1 frame every 2 seconds. For comparison, 3 control rabbits had pulse-inversion harmonic imaging with a mechanical index of 1.2 only, without contrast medium. Immediately after sonography, the animals we…